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KMID : 0545120090190060556
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Journal of Microbiology and Biotechnology
2009 Volume.19 No. 6 p.556 ~ p.559
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NF-κB Activation by Compounds Found in Platycodon grandiflorum Extract
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Hong Sung-Won
Yong Yeon-Joong
Kang Kyung-Rai
Shin Soon-Young
Lee Young-Han
Lim Yoong-Ho
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Abstract
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Compounds extracted from Platycodon grandiflorum were evaluated for an activation effect on nuclear factor-kappa B (NF-κB). In its active state, NF-κB turns on the expression of genes related to cell proliferation or death. NF-κB activators promote growth of neuron cells and can be used to control neurodegenerative diseases. The biological activity of P. grandiflorum extracts toward NF-κB had not yet been studied. Although the biological activity of several compounds extracted from P. grandiflorum was evaluated, only three exhibited any significant activation effect on NF-κB.
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KEYWORD
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Platycodon grandiflorum, lobetyol, lobetyolin, NF-κB
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